Away
San Francisco 49ers
Spread
-4.5
NFL Predictions
San Francisco 49ers vs Indianapolis Colts
Monday, December 22, 2025 at 8:15pm EST
VS
Home
Indianapolis Colts
Spread
+4.5
58%
42%
Spread
San Francisco 49ers -4.5
Indianapolis Colts +4.5
Moneyline
San Francisco 49ers -225
Indianapolis Colts +185
Total
Over 46.5 (-102)
Under 46.5 (-118)
Professional Picks
6 listed
Professional Picks On This Game
Tom Strickland
Spread pick
Simon Says
Spread pick
Matt O'Brien
Spread pick
Matt O'Brien
Total pick
Wes Salvato
Spread pick
Wes Salvato
Total pick