NFL Predictions

San Francisco 49ers vs Tampa Bay Buccaneers

Sunday, October 12, 2025 at 4:25pm EST

Away

San Francisco 49ers

Spread +3.5

Home

Spread -3.5

53%

47%

Spread San Francisco 49ers +3.5 Tampa Bay Buccaneers -3.5

Moneyline San Francisco 49ers +160 Tampa Bay Buccaneers -190

Total Over 46.5 (-110) Under 46.5 (-110)

Professional Picks

2 listed

Tom Strickland Total pick

In Progress

Simon Says Total pick

In Progress